Histopathological and Biochemical Toxic Alterations in Heart Tissue of Rats Exposed to Conventional Cigarette

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dc.creatorMoalai, Zainab Abdulrazzaq Hameed Al
dc.creatorSalman, Raghad Jawad
dc.creatorJebur, Hakim Bahlok
dc.date2023-04-16
dc.date.accessioned2023-08-21T09:04:41Z
dc.date.available2023-08-21T09:04:41Z
dc.descriptionThe present experimental study was carried out to identify histopathological and biochemical alterations in the hearts of rats exposed to conventional cigarette vapour. The methods included the use of 50 well-acclimated (25 treated and 25 control) rats for the personnel and laboratory procedures. The rats were subjected for 40 days (twice a day) to conventional cigarette vapour. After the end of the experimental exposure, the rats were sacrificed to prepare myocardial tissue-based microscopic slides. The blood albumin and cholesterol levels of the rats exposed to cigarette smoke were found to be significantly lower (p˂ 0.05) than those of the control animals. Alkaline phosphatase (ALP) and aspartate aminotransferase concentrations increased significantly (p˂0.05) in the smoking-treated group's liver enzyme profile (AST). When compared to that from the control animals, the level of lactate dehydrogenase (LDH), a marker of tissue damage, substantially (p˂0.05) increased in the cigarette-smoke-exposed rats. The histopathological outcome demonstrated the presence of swelling of the myocardial fibres. The indications revealed the occurrence of some vacuoles within the heart tissues. In addition, there was an increase in the oedema-originated spaces between the myocardial fibres. Moreover, unambiguous evidence of blood vessel-related light congestion. Furthermore, the light microscopy displayed the clear presence of myocardial fibres with an irregular pattern. The results, unveiled here, may indicate some dangerous effects of the vapour produced by conventional smoking on the myocardial tissues of Lab rats as indicated by the changes in the biochemical parameters and histopathological features.en-US
dc.formatapplication/pdf
dc.identifierhttps://univerpubl.com/index.php/scholastic/article/view/1037
dc.identifier.urihttp://dspace.umsida.ac.id/handle/123456789/21949
dc.languageeng
dc.publisherUniver Publishingen-US
dc.relationhttps://univerpubl.com/index.php/scholastic/article/view/1037/878
dc.sourceScholastic: Journal of Natural and Medical Education; Vol. 2 No. 4 (2023): Scholastic: Journal of Natural and Medical Education; 80-86en-US
dc.subjectCigarette dangeren-US
dc.subjectmyocardial histopathologyen-US
dc.subjectsmoking effectsen-US
dc.titleHistopathological and Biochemical Toxic Alterations in Heart Tissue of Rats Exposed to Conventional Cigaretteen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
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