Spectrophotometric Determination of Atenolol Using Zinc Oxide Nanoparticles Prepared From Lemon Peel Fruit Extract
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Background: A direct and inexpensive spectrophotometric approach was proposed to evaluate atenolol in its pure form and its pharmaceutical form atenolol using zinc oxide nanoparticles made from citrus peel extract. Measurements were taken at Tikrit University's College of Science between October 8, 2023, and January 18, 2024.
Methods: Determining up how much the addition of ATN to ZnONPs solution changes its wavelength is the most important objective of this research.
Results: For the combination of nano solution and medication, the results revealed the greatest absorption value at 282 nm wavelength. The linear relationship in the concentration range of 1-30 µg/mL followed the Beer-Lambert law with an excellent correlation coefficient R2 = 0.9964. The Sandell's significance value is 0.01976 µg/cm2, and the molar absorptivity value is 1.3476 × 104 L/mol.cm. A quantitative limit value of 0.7780 µg/ml and a detection limit value of 0.2567 µg/ml were obtained from the statistical and quantitative validation of the suggested approach.
Conclusion: The movement towards green synthesis methods has gained popularity due to its ease of preparation, affordability, and lack of environmental harm. This method has been successful in creating nanomaterials from green sources. Additionally, it was discovered that the wavelength value of ZnONPs increased from 278 nm to 282 nm when the drug atenolol (ATN) was introduced to the ZnONPs solution. This indicates that the molecules were bound to the drug solution.
Keywords
citrus peel extract, green synthesis, ZnONPs, atenolol