Primary and Secondary Hyperalgesia
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Univer Publishing
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According to the definition of the International Association for the Study of Pain, hyperalgesia means "an excessive reaction to moderate nociceptive stimulation". Primary hyperalgesia or peripheral sensitization is a reflection of activation and sensitization of nociceptive A-delta fibers and terminal windows of polymodal C-fibers in injured tissues. The basis of secondary hyperalgesia or central sensitization is spinal neuroplasticity and facilitating the transfer of nociceptive information to supraspinal structures.