Immune Response in Amoebiasis with Entamoeba Histolytica
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Description
Entamoeba histolytica is a protozoan parasite that causes amebiasis. Amebic pathogens can present clinically in a variety of ways, symptoms can range from being asymptomatic to having severe ones like diarrhea and extra-intestinal abscesses. Only 20% of those affected, like other infectious diseases, are thought to exhibit symptoms, and that the result of infection is determined by both the parasite's and humans' genetic make-up as well as external elements like the microbiome. Amebic pathogenicity involves several crucial stages, including the deterioration of the mucosal layer and infiltration into it, penetration into the tissues, adherence to the intestinal epithelium, and dissemination to other organs. Hepatic amoebiasis, which includes amoebic hepatitis and liver abscesses, is the most prevalent and dangerous effect of intestinal amebiasis. Although the mucosal layer in the digestive tract frequently serves as a main physical barrier against intestinal pathogens, the intestinal immune response is the secondary defense against E. histolytica infection. Mucosal immunoglobulins are the most significant component of the human gut defense system. Host protection against E. histolytica also depends on cell-mediated immune responses.
Keywords
Entamoeba histolytica, Immune response, pathogens