Possibilities of Interleukin-10 (IL-10) for Predicting the Development of Preeclampsia
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Univer Publishing
Abstract
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Hypertensive disorders during pregnancy are associated with high maternal and perinatal mortality, so it is very important for obstetricians to recognize severe cases with a poor prognosis in time.
The purpose of the study: To study the potential of interleukin-10 (IL-10) to predict the development of preeclampsia.
Materials and Methods: The study population consisted of 200 pregnant women. Of these, 100 had a risk of preeclampsia in the 1st and 2nd trimesters of pregnancy and 50 had a risk of preeclampsia in the 3rd trimester, and the control group consisted of 50 women with uncomplicated pregnancies. IL-10 was studied in pregnant women included in our study.
Results: In our study, the plasma level of IL-10 in women with preeclampsia was 23.3 pg/ml (specificity 89.7%, sensitivity 76.4%, accuracy 80.5%).
Conclusions: Thus, in preeclampsia, in contrast to normal pregnancy, the cytokine profile changes - there are lower concentrations of IL-10. Although the final pathogenesis of this pathology remains to be elucidated, on the basis of this it will be possible to develop an adequate therapy algorithm to save the life of the mother and child.
Keywords
preeclampsia, interleukin, IL-10, pregnancy, immunology